Executive Summary

This report describes current global research initiatives in the field of allergies. It focuses on the most common allergies, which affect more than 300 million persons worldwide: seasonal and perennial allergic rhinitis and food allergies.

Sales estimates from 2008 to 2013 are provided for the leading prescription allergy drugs and vaccines, as well as over-the-counter (OTC) allergy medicines in the U.S., European Union, Japan and rest of world area (defined as South America and the Caribbean, Middle East, Africa, and Asia except Japan). Forecasts include an analysis of the market forces affecting sales in each region, as well as a discussion of patent expirations of leading medications and the effects of generic competition on existing allergy drug sales.

Allergy medications and vaccines under development are discussed, with a comprehensive analysis of technology, stage of development and commercialization potential. This includes new molecular entities and indication expansions of medicines currently approved for other uses. For leading allergy drug candidates, sales estimates from 2009 to 2013 are provided.

Profiles of the 12 leading allergy drug developers offer details of these companies' capabilities, particularly focusing on R&D strength, pipeline products, strategic alliances and partnerships, and the effects of any recent merger or acquisition activity. A directory of more than five dozen leading players worldwide allows readers to access companies' own web sites for further review.

Information for this report was gathered from a wide variety of published sources; interviews with company representatives were then conducted to assess trends, and form the basis of the forecasting and competitive analysis.

This report is designed for business development and other senior executives, marketers, R&D managers, investors, VCs, consultants, entrepreneurs and others who require an in-depth understanding of the current status of the allergy therapeutics market and potential new products. More than 50 detailed tables or figures provide key data about items such as strategic alliances, M&As, market size, segments and the like. 

Table of Contents

Executive Summary
  1. Overview of the Global Allergy Medications Market
    1.1 Allergies as a Medical Condition
      1.1.1 Types of Allergies
      1.1.2 Signs and Symptoms
      1.1.3 Physiological Response
         Table 1-1. Gell & Coombs Classification of Allergic Reactions
      1.1.4 Prevalence
        Table 1-2. Global Prevalence of Allergies

Region

Population (Million)

Prevalence of Rhinitis (Million)

Prevalance of Food Allergies (Million)

  1.2 Medical Treatment of Allergies
    1.2.1 Prescription Medications: Current Usage & Unmet Needs
        Table 1-3. Leading Prescription Allergy Medications

Product

Manufacturer

Type

      1.2.1.1 U.S.
        Table 1-4. U.S. DTC Advertising for Leading Rx and OTC Allergy Medications 2008

Product

Manufacturer

Budget ($ Million)

      1.2.1.2 Europe
      1.2.1.3 Japan
      1.2.1.4 ROW
    1.2.2 Non-Prescription Products: Current Usage & Unmet Needs
        Table 1-5. Leading OTC Allergy Medications

Product

Manufacturer

Type

      1.2.2.1 U.S.
      1.2.2.2 Europe
      1.2.2.3 Japan
      1.2.2.4 ROW

2 Global Allergy Medications Market Forecast 2008 - 2013
  2.1 Rx Allergy Medications Market
    2.1.1 Rx Allergy Drug Market Forecast by Product
      2.1.1.1 Growth Drivers
        Table 2-1. Rx Allergy Drug Market Forecast 2008 - 2013 by Product in $Million

Product	2008	2009	2010	2011	2012	2013	CAGR

      2.1.1.2 Market Restraints
        Table 2-2. U.S. Patent Expirations of Leading Prescription Allergy Drugs

Product

Manufacturer

Patent/Exclusivity Expiration

    2.1.2 Rx Allergy Drug Market Forecast by Region
        Table 2-3. Rx Allergy Drug Market Forecast, 2008 - 2013 by Region in $ Million

Region	2008	2009	2010	2011	2012	2013	CAGR

    2.1.3 Rx Allergy Drug Market Forecast by Product Class
        Table 2-4. Rx Allergy Drug Market Forecast, 2008 - 2013 by Product Class in $ Million

Class	2008	2009	2010	2011	2012	2013	CAGR

        Table 2-5. Rx Allergy Drug Market Product Segments Share, 2008 vs. 2013

Class	2008(8M)	%		2013($M)	%

        Figure 2-1. Rx Allergy Drug Market Product Segments Share, 2008
        Figure 2-2. Rx Allergy Drug Market Product Segments Share, 2013
  2.2 OTC Allergy Drug Market
    2.2.1 OTC Allergy Drug Market Forecast by Product
        Table 2-6. OTC Allergy Drug Market Forecast, 2008 - 2013 by Product in $Million

Products	2008	2009	2010	2011	2012	2013	CAGR

    2.2.2 Growth Drivers
    2.2.3 Market Restraints
    2.2.4 OTC Allergy Drug Market Forecast by Region
        Table 2-7. OTC Allergy Drug Market Forecast, 2008 - 2013 by Region in $ Million

Region	2008	2009	2010	2011	2012	2013	CAGR

    2.2.5 OTC Allergy Drug Market Forecast by Product Class
        Table 2-8. OTC Allergy Drug Market Forecast, 2008 - 2013 by Product Class in $ Million

Class	2008	2009	2010	2011	2012	2013	CAGR

  2.3 Rx & OTC Allergy Drug Market
    2.3.1 Rx & OTC Allergy Drug Market Forecast by Leading Manufacturers

        Table 2-9. RX & OTC Allergy Drug* Sales of Leading Manufacturers, 2008 - 2013 in $Million

Class	2008	2009	2010	2011	2012	2013	CAGR

    2.3.2 Rx & OTC Allergy Drug Market Share of Leading Drug Manufacturers
        Table 2-10. Rx & OTC Market Shares of Leading Allergy Drug Manufacturers, 2008 vs. 2013

Class	2008(8M)	%		2013($M)	%

        Figure 2-3. Rx & OTC Market Shares of Top Allergy Drug Manufacturers, 2008
        Figure 2-4. Rx & OTC Market Shares of Top Allergy Drug Manufacturers, 2013

3. Allergy Drug Development: New Molecular Entities
        Table 3-1. Key Characteristics of NMEs, Generics and Indication Expansions

Segment	NME	Generic	Indication Expansion

3.1 All Allergy Drug Developers Position
3.1.1 Challenges in Allergy Drug Development
Table 3-2. All Allergy Drug Developers Product Position Overview

Product	Segment	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

  3.2 Key Products Under Development
        Figure 3-1. Allergy Compounds Tested by Phase of Development
    3.2.1 Antihistamines
      3.2.1.1 Physiology and Mechanism of Action
      3.2.1.2 Leading Antihistamine Allergy Drug Candidates

        Table 3-3. Antihistamine Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

    3.2.2 Corticosteroids
      3.2.2.1 Physiology and Mechanism of Action
      3.2.2.2 Leading Corticosteroid Allergy Drug Candidates
        Table 3-4. Corticosteroid Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

    3.2.3 Mast Cell Inhibitors
      3.2.3.1 Physiology and Mechanism of Action
        Figure 3-2. The Role of Mast Cells in Allergy Response
      3.2.3.2 Leading Mast Cell Inhibitor Allergy Drug Candidates
        Table 3-5. Mast Cell Inhibitors Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

    3.2.4 Allergy Immunotherapy
      3.2.4.1 Physiology and Mechanism of Action
      3.2.4.2 Leading Immunotherapy Allergy Drug Candidates
        Table 3-6. Immunotherapy Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

    3.2.5 Vaccines
      3.2.5.1 Physiology and Mechanism of Action
        Figure 3-3. Production of TH2 Cytokines
      3.2.5.2 Leading Allergy Vaccine Candidates
        Table 3-7. Vaccine Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

    3.2.6 Other Types of Allergy Drugs
      3.2.6.1 Physiology and Mechanism of Action
      3.2.6.2 Other Leading Allergy Candidates
        Table 3-8. Other Allergy Drug Developers Product Position

Product	Sub-segment	Commercial Company & Stage	Startup Company & Stage	University/ Research Institute

  3.3 Global Market Forecast for New Allergy Drugs, 2008 - 2013
    3.3.1 New Allergy Drug Market Forecast: Total and Segment Market
        Table 3-9. Sales of New Allergy Drugs by Segment, 2008 - 2013

Product ($million)	2008	2009	2010	2011	2012	2013

        Figure 3-4. Market Shares of New Allergy Drugs by Segment, 2013
    3.3.2 Growth Drivers
      3.3.2.1 The Importance of Patents
    3.3.3 Market Restraints

4. Allergy Drug Development: Indication Expansion
  4.1 Indication Expansion for New Usage
        Table 4-1. Selected Recent Allergy Drug Indication Expansions, U.S.

Manufacturer	Product	Segment	Details

    4.1.1 The Economic Benefits of Indication Expansion
        Table 4-2. U.S. R&D Expenditure for New Medicines by the Pharma-Industry

2006	2007	2008	2009 (Projected)

    4.1.2 Challenges in Allergy Drug Indication Expansion
        Figure 4-1. Cost and Time Savings of Indication Expansions
  4.2 Key Products Under Development
    4.2.1 Database of Allergy Indication Expansion Initiatives by Company
        Table 4-3. Selected Allergy Drug Indication Expansion Trials

Manufacturer	Product	Segment	Objective

    4.2.2 Leading Areas of R&D Activity
      4.2.2.1 Clarinex
      4.2.2.2 Nasonex
      4.2.2.3 Patanase
      4.2.2.4 Singulair
      4.2.2.5 Veramyst
      4.2.2.6 Xolair
      4.2.2.7 Xyzal
  4.3 Global Market Forecast for Allergy Drug Indication Expansions
        Table 4-4. Sales of Allergy Drug Indication Expansions, 2008 - 2013 in $ Million

Product	2008	2009	2010	2011	2012	2013

        Table 4-5. Product Market Share of Allergy Drug Indication Expansions, 2009 vs. 2013

Product	2009	%		2013	%

        Figure 4-2. Product Market Share of Allergy Drug Indication Expansions, 2009
        Figure 4-3. Product Market Share of Allergy Drug Indication Expansions, 2013
    4.3.1 Growth Drivers
    4.3.2 Market Restraints

5. Allergy Drug Development: Basic Research
  5.1 Basic Research Group & Activity
        Table 5-1. Leading Organizations & Details for Basic Allergy Research

Country	Group	Details

    5.1.1 Challenges in Basic Allergy Research
        Figure 5-1. National Institutes of Health Research Budget by Disease Area, Fiscal 2008
  5.2 Key Areas of Investigation
        Table 5-2. Recent Basic Research in the Field of Allergies

Group/s	Product Developer?	Details

  5.3 Unanswered Questions

6. Strategic Alliances for Allergy Drug Development
  6.1 Types of Strategic Alliances
        Figure 6-1. Comparison of Selected Deal Types
  6.2 Current Strategic Alliances for Allergy Drug Development
        Table 6-1. Ongoing Strategic Alliances for Allergy Drug Development

Month-Year	Deal Type	Technology	Buyer	Developer	Details

7. Activities of the Leading Allergy Drug Developers
Common Research Item:
1) Table: Product Profile:

Manufacturer	Product	Region/ Application	Phase

2) R&D Strength and Capabilities
3) Marketed Allergy Drugs
4) Allergy Drug Pipeline
5) Table: Profile

Common Research Item

Contact

URL

Allergy Drug Revenue 2008 ($Million)

Approximate Allergy R&D Budget ($Million)

# of Researchers (Allergy)

Allergy Product Class

Allergy R&D Strength

Marketed Allergy Drugs & Sales 2008

Allergy Drug Pipeline

Strategic Alliances for Allergy

  7.1 Alcon Research
  7.2 Allergy Therapeutics
  7.3 AstraZeneca
  7.4 GlaxoSmithKline
  7.5 Johnson & Johnson
  7.6 Meda AB
  7.7 Merck
  7.8 Novartis
  7.9 Sanofi-Aventis
  7.10 Schering-Plough
  7.11 Sepracor
  7.12 UCB Pharma

8. Total Allergy Drug Market: Forecasts & Directions
        Table 8-1. Total Allergy Drug Sales by Segment, 2008 - 2013 in $Million

Product	2008	2009	2010	2011	2012	2013	CAGR

        Figure 8-1. Total Allergy Drug Sales Growth by Segment, 2008 - 2013
        Figure 8-2. Allergy Drug Market Share by Segment, 2008
        Figure 8-3. Allergy Drug Market Share by Segment, 2013

9. Other Top Companies with Allergy Projects
        Table 9-1. Other Top Companies with Late Stage Allergy Projects

Company	Product Class	Key Products	Stage

        Table 9-2. Other Top Companies with Early Stage Allergy Projects

Company	Product Class	Key Products	Stage

10. Database of Allergy Drug Developers
  

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